Polymorphic patterns of the merozoite surface protein-3β in Korean isolates of Plasmodium vivax
نویسندگان
چکیده
منابع مشابه
diversity of merozoite surface protein-3β gene of plasmodium vivax isolates from iran
background: plasmodium vivax malaria accounts for approximately 88% of malaria cases in iran. there is limited information on genetic diversity of p. vivax in the country and a need to develop and apply an effective vaccine against the disease is necessary. among many potential candidates, msp -3β gene is promising target. this study was designed and carried out to determine the variation of...
متن کاملanalysis of plasmodium vivax merozoite surface protein-1 gene sequences
the emergence of plasmodium vivax in dashte moghan in northwestern iran has become a major concern for iranian's health officials. knowledge of genetic make up of the p. vivax populations in this area would give us an insight into the origin of the prevalent infections and the possible routes they are introduced. this paper reports the analysis of a variable region between the two interspecies ...
متن کاملMolecular genetic characterization of the merozoite surface protein 1 Gene of Plasmodium vivax from reemerging Korean isolates.
Plasmodium vivax merozoite surface protein 1 (PvMSP-1) has been considered a major candidate for the development of an antimalaria vaccine, but the molecule exhibits antigenic diversity among isolates. The extent of genetic polymorphism in the region between interspecies conserved blocks 4 and 5 (ICB4 and ICB5) of the PvMSP-1 gene was analyzed for 30 Korean isolates. Two genotypes, SK-A and SK-...
متن کاملAntigenicity and Immunogenicity of Plasmodium vivax Merozoite Surface Protein-3
A recent clinical trial in African children demonstrated the potential utility of merozoite surface protein (MSP)-3 as a vaccine against Plasmodium falciparum malaria. The present study evaluated the use of Plasmodium vivax MSP-3 (PvMSP-3) as a target antigen in vaccine formulations against malaria caused by P. vivax. Recombinant proteins representing MSP-3α and MSP-3β of P. vivax were expresse...
متن کاملThe Plasmodium vivax Merozoite Surface Protein 3β Sequence Reveals Contrasting Parasite Populations in Southern and Northwestern Thailand
BACKGROUND Malaria control efforts have a significant impact on the epidemiology and parasite population dynamics. In countries aiming for malaria elimination, malaria transmission may be restricted to limited transmission hot spots, where parasite populations may be isolated from each other and experience different selection forces. Here we aim to examine the Plasmodium vivax population diverg...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2014
ISSN: 1475-2875
DOI: 10.1186/1475-2875-13-104